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目的探讨成人不同程度的支气管哮喘患者β2-肾上腺受体(β2-AR)功能变化情况。方法选择东莞市人民医院门诊2007年12月～2009年1月确诊为支气管哮喘患者83例,依据严重程度进行分级,同时选取同期32例健康者作为对照组,测定血cAMP值。结果在对照组、支气管哮喘轻、中、重度持续组cAMP分别为:(26.43±4.92)μmol/L、(23.49±5.99)μmol/L、(14.34±4.43)μmol/L和(11.08±3.72)μmol/L,四组比较差异均有统计学意义(P<0.05)。结论支气管哮喘患者存在β2-肾上腺受体功能减退,且随着病情严重程度的增加而减低。
Objective To investigate the functional changes of β2-adrenergic receptor (β2-AR) in adults with different degrees of bronchial asthma. Methods Eighty-three patients diagnosed as bronchial asthma from December 2007 to January 2009 in Dongguan City People’s Hospital were selected and graded according to their severity. Meanwhile, 32 healthy subjects were selected as the control group to measure the blood cAMP value. Results In the control group, the levels of cAMP were (26.43 ± 4.92) μmol / L, (23.49 ± 5.99) μmol / L, (14.34 ± 4.43) μmol / L and (11.08 ± 3.72) μmol / L, the differences between the four groups were statistically significant (P <0.05). CONCLUSIONS: β2-adrenoceptor dysfunction exists in patients with bronchial asthma and decreases as the severity of the disease increases.