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目的探讨特发性非特异性间质性肺炎的临床病理学特征和鉴别诊断。方法对6例特发性非特异性间质性肺炎进行临床、影像学、组织病理学和免疫组化观察,并复习相关文献。结果高分辨CT显示双肺对称性毛玻璃样阴影。镜下肺组织呈均匀一致性病变,主要表现为间质慢性炎症和纤维化,肺泡间隔增宽。免疫组化示增生的肺泡上皮和支气管上皮CK、EMA(+)。结论特发性非特异性间质性肺炎是一种重要的特异性间质性肺炎类型,应注意与寻常型间质性肺炎、淋巴细胞性间质性肺炎及过敏性肺炎等进行鉴别,对指导临床治疗和判断预后具有非常重要的意义。
Objective To investigate the clinicopathological characteristics and differential diagnosis of idiopathic nonspecific interstitial pneumonia. Methods Six cases of idiopathic nonspecific interstitial pneumonia were observed by clinical, radiological, histopathological and immunohistochemical methods, and the related literatures were reviewed. Results High-resolution CT showed a bilateral symmetrical frosted glass-like shadow. Microscopic lung tissue was uniform and consistent lesions, mainly as interstitial chronic inflammation and fibrosis, alveolar septum widened. Immunohistochemistry showed hyperplastic alveolar epithelium and bronchial epithelial CK, EMA (+). Conclusions Idiopathic nonspecific interstitial pneumonitis is an important type of interstitial pneumonia. It should be noted that it should be distinguished from common interstitial pneumonia, lymphocytic interstitial pneumonia and allergic pneumonia. Clinical treatment and prognosis are of great importance.