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目的探究依那普利叶酸治疗H型高血压的临床效果。方法 40例H型高血压患者,随机分为对照组及观察组,每组20例。对照组使用依那普利片治疗,观察组使用依那普利叶酸治疗。对比两组患者治疗前后舒张压(DBP)、收缩压(SBP)、同型半胱氨酸(Hcy)、空腹血糖(FPG)、空腹胰岛素(FINS)水平。结果治疗前,两组患者的DBP、SBP、Hcy水平比较,差异均无统计学意义(t=1.343、1.049、0.258,P>0.05);治疗后,观察组患者的DBP、SBP、Hcy水平均低于对照组,差异均具有统计学意义(t=5.769、2.087、2.916,P<0.05)。治疗前,两组患者的FPG、FINS水平比较,差异均无统计学意义(t=0.066、0.281,P>0.05);治疗后,观察组患者的FPG、FINS水平均低于对照组,差异均具有统计学意义(t=3.830、2.940,P<0.05)。结论对于H型高血压患者,使用依那普利叶酸治疗,除了可稳定血压,降低不良反应发生之外,还能够降低血Hcy水平,值得进一步推广。
Objective To investigate the clinical efficacy of enalapril folate in the treatment of Hypertension. Methods Forty Hypertensive patients were randomly divided into control group and observation group, 20 cases in each group. The control group was treated with enalapril and the observation group with enalapril folate. The levels of DBP, SBP, Hcy, FPG and FINS were compared between the two groups before and after treatment. Results Before treatment, the levels of DBP, SBP and Hcy in both groups had no significant difference (t = 1.343,1.049,0.258, P> 0.05). After treatment, the levels of DBP, SBP and Hcy in the observation group Lower than the control group, the differences were statistically significant (t = 5.769,2.087,2.916, P <0.05). Before treatment, there was no significant difference in FPG and FINS between the two groups (t = 0.066,0.281, P> 0.05). After treatment, FPG and FINS in the observation group were lower than those in the control group Statistically significant (t = 3.830, 2.940, P <0.05). Conclusions For Hypertension patients, the use of enalapril folate treatment, in addition to stabilize blood pressure, reduce adverse reactions, but also can reduce blood Hcy levels, it is worth further promotion.