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甲氧基雌二醇(2-Methoxyestradiol,2-ME)作为体内雌激素的内源性生理代谢产物。具有抑制细胞增殖、诱导细胞凋亡、抗血管形成,低细胞毒性及低雌激素活性等生物学特性,由此在肿瘤界日益受到重视。在妇产科方面,妊娠期孕妇体内2-ME的浓度要明显高于月经期,且随孕周发展逐渐升高,2-ME是维持妊娠期胎盘发育的重要因子之一,其量的缺乏将导致临床子痫前期的发生。
Methoxyestradiol (2-ME) acts as an endogenous physiological metabolite of estrogen in the body. It has biological characteristics such as inhibiting cell proliferation, inducing apoptosis, anti-angiogenesis, low cytotoxicity and low estrogen activity, which are gaining more and more attention in the tumor field. In the field of obstetrics and gynecology, the concentration of 2-ME in pregnant women during pregnancy is significantly higher than the menstrual period, and gradually increased with gestational age, 2-ME is one of the important factors to maintain placental development in pregnancy, the lack of its amount Will lead to the occurrence of clinical preeclampsia.