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目的 观察消瘀胶囊对预防家兔高脂血症形成的影响。方法 48只新西兰兔按血清胆固醇 (TC)水平平均分成 6组 ,即正常对照组 ,高脂模型组 ,消瘀胶囊小剂量组 (2 5mg/kg) ,中剂量组 (50mg/kg) ,大剂量组 (1 0 0mg/kg) ,血脂康组 (65mg/kg)。除正常对照组 ,余各组给予高脂饲料及相应药物 ,连续服用 31天后 ,测定各组兔空腹血脂水平。结果 消瘀胶囊各组可使兔血清TC ,低蛋度脂蛋白胆固醇 (LDL -c)显著地低于高脂模型组 (P <0 .0 1 ) ;使血清甘油三酯 (TG)下降 1 3 .2 %～ 43 .6 % ,尤其大剂量组明显 (P <0 .0 5) ;对高密度脂蛋白胆固醇 (HDL -c)虽然没有升高作用 ,但可使TC/HDL -c比值明显下降 (P <0 .0 1 )。结论 消瘀胶囊具有预防家兔高脂血症形成的作用
Objective To observe the effect of Xiaoying Capsule on the prevention of hyperlipidemia in rabbits. Methods Forty-eight New Zealand rabbits were divided into six groups according to serum cholesterol (TC) levels, namely normal control group, high-fat model group, Xiaoyu capsule low-dose group (25mg/kg), middle-dose group (50mg/kg), large Dose group (100mg/kg), Xuezhikang group (65mg/kg). Except for the normal control group, the remaining groups were given high-fat diet and corresponding drugs. After 31 days of continuous administration, the fasting lipid levels of each group were determined. Results The serum TC and LDL-c of rabbits in Xiaoying capsule group were significantly lower than those in the high-fat model group (P < 0.01), and serum triglyceride (TG) was decreased by 1 From 3.2% to 43.6%, especially in the high-dose group (P < 0.05); although there was no increase in high-density lipoprotein cholesterol (HDL-c), TC/HDL-c ratio could be achieved. Significantly decreased (P < 0.01). Conclusion Xiaozhi Capsule can prevent rabbit hyperlipidemia from forming