目的:为了探索更好的且具有较高的活性和对炎症性肠病毒副作用少的4-氨基水杨酸前药。方法:首先以4-ASA为原料依次用氯甲酸苄酯和乙酸酐分别保护氨基和酚羟基,然后再氢化还原脱去氨基上的保护基,合成的新化合物经MS、IR、1H-NMR、13C-NMR确证。结果:本实验合成了3个4-氨基水杨酸与不饱和脂肪酸形成的酰胺类化合物。结论:该合成路线是合理和可行的。 Purpose: To explore 4-aminosalicylic acid prodrugs that are better and have higher activity and less side effects on inflammatory enterovirus. Methods: The amino and phenolic hydroxyl groups were protected by benzyl chloroformate and acetic anhydride respectively using 4-ASA as starting material, and then the protective groups of the amino groups were removed by hydrogenation. The new compounds were characterized by MS, IR, 1H-NMR, 13C-NMR confirmed. Results: Three 4-aminosalicylic acid and unsaturated fatty acid amide compounds were synthesized in this experiment. Conclusion: This synthetic route is reasonable and feasible.