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目的:研究木犀草素抗小鼠Lewis肺癌和4T1乳腺癌转移的作用。方法:采用小鼠自发性肿瘤转移和被动转移模型,通过检测肿瘤转移结节数及脏器指数来研究木犀草素对小鼠Lewis肺癌和4T1乳腺癌转移的影响。结果:木犀草素可有效抑制小鼠Lewis和4T1肺转移结节数,增强小鼠对癌症的相伴免疫反应。结论:木犀草素有明显的抗转移作用。
OBJECTIVE: To study the effect of luteolin on the metastasis of Lewis lung carcinoma and 4T1 breast cancer in mice. Methods: The spontaneous tumor metastasis and passive metastasis models of mice were used to study the influence of luteolin on the metastasis of Lewis lung cancer and 4T1 breast cancer in mice by detecting the number of metastatic nodules and the organ index. Results: Luteolin could effectively inhibit the number of lung metastasis of Lewis and 4T1 mice and enhance the concomitant immune response to cancer in mice. Conclusion: Luteolin has obvious anti-metastasis effect.