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目的:探讨人类巨细胞病毒(HCMV)近期感染与冠心病(CAD)的关系。方法:用ELISA法检测正常人群(365例)和CAD(急性心肌梗死41例、心绞痛79例和隐匿型CAD111例)人群血清HCMV-IgM抗体,并通过检测血清肌酸肌酶同工酶(CK-MB)将CAD人群分为急性组和慢性组,比较两组HCMV-IgM抗体水平的差异。结果:在231例病人血清标本中,HCMV-IgM抗体阳性95例(41.1%);在对照组中,365例健康查体者HCMV-IgM抗体阳性84例(23.0%)。两组相比较有极显著性差异(χ2=22.08,P<0.0001)。急性心肌梗死组阳性24例(58.5%)同心绞痛组31例(39.2%)和隐匿型CAD组40例(36%)相比,HCMV-IgM抗体阳性率有显著性差异(χ2=4.04,P<0.05和6.21,P<0.025)。CK-MB阳性组43例(51.2%)和CK-MB阴性组55例(37.4%)相比,HCMV-IgM抗体阳性率有显著性差异(χ2=4.15,P<0.05)。结论:CAD人群有较高的HCMV-IgM抗体阳性率,急性CAD人群的HCMV-IgM抗体阳性率要显著高于慢性CAD。
Objective: To investigate the relationship between recent infection of human cytomegalovirus (HCMV) and coronary heart disease (CAD). Methods: Serum HCMV-IgM antibody was detected by enzyme-linked immunosorbent assay (ELISA) in 365 cases of normal people and 41 cases of CAD, 79 cases of angina pectoris and 111 cases of occult CAD. Serum HCMV- MB) The CAD population was divided into acute group and chronic group, and the differences of HCMV-IgM antibody levels between the two groups were compared. Results: Among the 231 patients, HCMV-IgM was detected in 95 cases (41.1%). In the control group, HCMV-IgM was detected in 84 cases (23.0%) of 365 healthy people. There was significant difference between the two groups (χ2 = 22.08, P <0.0001). The positive rate of HCMV-IgM antibody in 24 patients (58.5%) in acute myocardial infarction group was significantly different from that in 31 patients (39.2%) in concentric angiography group and 40 patients (36%) in occult CAD group (χ2 = 4.04, P <0.05 and 6.21, P <0.025). The positive rate of HCMV-IgM antibody was significantly different between CK-MB positive group (51.2%) and CK-MB negative group 55 (37.4%) (χ2 = 4.15, P <0.05). Conclusion: The positive rate of HCMV-IgM antibody in CAD population is higher than that in chronic CAD. The positive rate of HCMV-IgM antibody in CAD population is significantly higher than that in chronic CAD.