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目的探讨检测妊娠期甲状腺自身抗体对妊娠期糖尿病(GDM)产妇甲状腺功能的评估价值。方法选择2014年2~8月在该院确诊为GDM的产妇140例纳入观察组,80例健康产妇纳入对照组。检测促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、抗甲状腺球蛋白抗体(TGAb)和抗甲状腺过氧化物酶抗体(TPOAb)。结果两组产妇TSH、T3、T4、FT3水平相比,差异无统计学意义(P>0.05);观察组FT4水平低于对照组,差异有统计学意义(P<0.05);观察组TGAb、TPOAb及二者联合检测阳性率均明显高于对照组,差异有统计学意义(P<0.05)。结论甲状腺抗体检测对GDM产妇甲状腺功能评价具有重要作用,能及时发现甲状腺病变,有利于改善妊娠结局。
Objective To investigate the value of detecting thyroid autoantibodies during pregnancy for thyroid function in gestational diabetes mellitus (GDM). Methods Forty-four maternal women with GDM diagnosed in our hospital from February to August 2014 were enrolled in the observation group and 80 healthy mothers were enrolled in the control group. Thyrotropin (TSH), triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroglobulin antibody (TGAb) And anti-thyroid peroxidase antibody (TPOAb). Results There was no significant difference in the levels of TSH, T3, T4 and FT3 between the two groups (P> 0.05). The FT4 level in the observation group was lower than that in the control group (P <0.05) The positive rates of TPOAb and their combined detection were significantly higher than those of the control group (P <0.05). Conclusions Detection of thyroid antibodies plays an important role in the assessment of thyroid function in GDM males, which can detect thyroid lesions in time and improve the outcome of pregnancy.