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目的:探讨米索前列醇片在初次早早孕(≤42天)人工流产术前应用的可行性、有效性及安全性。方法:将300例初次妊娠,孕周≤6周,拟行人工流产的妇女随机分为口服米索组100例(A组)、阴道放置米索组100例(B组)、未使用米索对照组(C组)。A组术前2h口服米索前列醇片400μg,B组术前2 h阴道放置米索前列醇片400μg。观察并比较术前用药的两组不良反应发生率、宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生情况。结果:B组不良反应发生率低于A组,差异有统计学意义(P<0.01);A、B两组间术中宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生率差异均无统计学意义(P>0.05),但与C组比较差异有统计学意义。结论:米索前列醇片口服和阴道放药都可作为初次早早孕人工流产术前的给药方法。更推荐不良反应较小的阴道放药。
Objective: To investigate the feasibility, effectiveness and safety of misoprostol in preoperative abortion (≤42 days). Methods: A total of 300 women with first trimester pregnancy and gestational weeks ≤6 weeks were divided into 100 cases of oral misoprostol (group A), 100 cases of vaginal misoprostol (group B), and no misoprostol Control group (C group). In group A, 400 μg of misoprostol was administered 2 h before operation and 400 μg of misoprostol was placed in vagina of group B two hours before operation. The incidence of adverse reactions, cervical dilation, intraoperative blood loss, operation time and postoperative cervical adhesions were observed and compared. Results: The incidence of adverse reactions in group B was significantly lower than that in group A (P <0.01). The cervical dilatation, intraoperative blood loss, operation time and the incidence of postoperative cervical adhesion There was no significant difference between the two groups (P> 0.05), but the difference was statistically significant compared with C group. Conclusion: Both misoprostol and oral vaginal suppository can be used as the method of premature abortion. More recommended minor adverse vaginal drug release.