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目的探讨70岁以上老年人口腔黏膜鳞癌综合治疗的疗效及其围手术期的处理原则。方法收集1991-2001年行计划性诱导性顺铂为主综合治疗的年龄≥70岁(≥70岁组)的72例患者治疗情况,与同期同治疗方案年龄<70岁(<70岁组)72例患者和同期单纯手术根治的26例患者(单纯手术组)的情况进行对比。结果≥70岁组12、24、36个月生存率分别是84.6%、73.0%和68.5%,<70岁组为85.8%、75.3%和69.1%,手术组为52.7%、48.5%和39.7%。≥70岁组和<70岁组3年生存率比较,差异无统计学意义(P>0.05);≥70岁组和手术组3年生存率比较,差异有统计学意义(P<0.05)。结论对70岁以上老年人口腔黏膜鳞状细胞癌采用以顺铂为主的综合治疗,可提高患者3年生存率,60～80mg 的顺铂剂量70岁以上老年人能够耐受。
Objective To investigate the efficacy and perioperative management of oral mucosal squamous cell carcinoma in the elderly over 70 years old. Methods The clinical data of 72 patients aged 70 years or older (≥70 years old) who underwent combined chemotherapy of scheduled cisplatin-based chemotherapy from 1991 to 2001 were collected and compared with those of the same treatment regimen (<70 years old <70 years old) Twenty-seven patients were compared with 26 patients treated with radical surgery alone (surgery alone group). Results The survival rates at 12, 24 and 36 months were 70.6%, 73.0% and 68.5% in patients ≥70 years old, 85.8%, 75.3% and 69.1% in patients under 70 years old, 52.7%, 48.5% and 39.7% . The 3-year survival rates of ≥70 years old and <70 years old group were not statistically significant (P> 0.05). The 3-year survival rates of ≥70 years old group and operation group were statistically significant (P <0.05). Conclusion The comprehensive treatment of oral mucosa squamous cell carcinoma of the elderly over 70 years with cisplatin can improve the 3-year survival rate of patients and 60-80 mg of cisplatin can tolerate the elderly over 70 years of age.