抗微生物多肽和蛋白是机体先天性防御系统的重要组成成份,防御素(defensins)是近年来颇受关注的一组抗微生物多肽,人体已发现的防御素有9种,分为α和β两类防御素。本文综述了防御素的分类、结构特征、组织分布、抗微生物性能及机制,以及在口腔医学中的研究和应用。 Anti-microbial peptides and proteins are important components of the congenital defense system of the body. Defensins are a group of antimicrobial peptides that have drawn much attention in recent years. Nine defensins have been found in human body, which are divided into α and β Class defensins. This review summarizes the classification, structural features, tissue distribution, antimicrobial properties and mechanisms of defensins, as well as the research and application in dentistry.