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HERG基因编码的蛋白在心室复极过程中很重要,HERG基因突变导致遗传性长QT综合征。获得性长QT综合征也与HERG基因相关。随着分子遗传学的进展,HERG基因突变如何导致长QT综合征的分子机制正逐步被揭示。
The HERG gene encodes a protein that is important in ventricular repolarization, and mutations in the HERG gene lead to hereditary long QT syndromes. Acquired long QT syndrome is also associated with the HERG gene. With the progress of molecular genetics, the molecular mechanism of HERG gene mutation leading to long QT syndrome is gradually revealed.