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目的对围手术期宫颈癌患者进行心理干预,探讨心理干预对其免疫功能的影响。方法选择2013年1月-2015年1月杭州师范大学附属医院诊断为宫颈癌的86例患者作为研究对象,将其随机分为心理干预组和对照组,对照组患者入院后给予常规的心理护理和健康宣教,心理干预组在常规的心理护理和健康宣教的基础上给予心理干预:包括认知干预、放松疗法、音乐疗法、家庭支持和运动疗法。患者入院后当天及术后2周测定血液中CD3、CD4、CD8含量和血清TNF-α含量,比较两组患者心理干预前后血液中CD3、CD4、CD8含量和血清TNF-α含量变化情况。结果心理干预前心理干预组和对照组血液CD3、CD4、CD8和CD4/CD8含量比较,差异无统计学意义(P>0.05),心理干预后心理干预组的血液CD3、CD4含量高于对照组(P<0.05),CD8含量低于对照组(P<0.05),CD4/CD8值高于对照组(P<0.05),心理干预组心理干预后血液CD3、CD4含量高于干预前(P<0.05),CD8含量低于干预前(P<0.05),CD4/CD8值高于干预前(P<0.05),心理干预前,心理干预组和对照组血清TNF-α含量和对照组比较没有差异(P>0.05),心理干预后,心理干预组的血清TNF-α含量低于对照组(P<0.05);心理干预组干预后的血清TNF-α含量低于干预前(P<0.05),对照组干预后的血清TNF-α含量低于干预前(P>0.05)。结论心理干预能够改变围手术期宫颈癌患者血液中CD3、CD4、CD8和CD4/CD8含量以及血清TNF-α含量,能够提高宫颈癌患者的免疫功能。
Objective To investigate the psychological intervention of patients with cervical cancer during perioperative period to explore the impact of psychological intervention on their immune function. Methods From January 2013 to January 2015, 86 patients diagnosed as cervical cancer in Hangzhou Normal University Affiliated Hospital were randomly divided into psychological intervention group and control group. Patients in control group were given regular psychological nursing And Health Discipline and Mental Intervention groups give psychological interventions based on conventional psychological care and health education: cognitive interventions, relaxation therapy, music therapy, home support, and exercise therapy. The levels of CD3, CD4, CD8 and TNF-α in blood were measured on the day after admission and 2 weeks after operation. The levels of CD3, CD4, CD8 and TNF-α in blood were compared between the two groups before and after psychological intervention. Results There was no significant difference in the blood levels of CD3, CD4, CD8 and CD4 / CD8 between the psychological intervention group and the control group before psychological intervention (P> 0.05), and the levels of CD3 and CD4 in the psychological intervention group were higher than those of the control group (P <0.05). The level of CD8 was lower in the intervention group than in the control group (P <0.05), while the level of CD4 / CD8 in the intervention group was higher than that in the control group (P <0.05). The level of CD4 / CD8 was higher than that before intervention (P <0.05). There was no difference in serum TNF-α levels between psychological intervention group and control group before psychological intervention (P <0.05). After psychological intervention, the level of serum TNF-αin the psychological intervention group was lower than that in the control group (P <0.05) The level of serum TNF-α in the control group was lower than that before the intervention (P> 0.05). Conclusion Psychological intervention can change the content of CD3, CD4, CD8 and CD4 / CD8 and the level of serum TNF-α in the blood of patients with cervical cancer during perioperative period, which can improve the immune function of patients with cervical cancer.