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目的:比较黄体酮与绒毛膜促性腺激素对早期先兆流产患者的症状缓解时间和保胎成功率。方法:选取2010年3月—2012年1月间收治的早期先兆流产患者62例,将其随机分为黄体酮组和绒毛膜促性腺激素组,每组31例;黄体酮组患者均给予黄体酮胶囊口服治疗,绒毛膜促性腺激素组患者均给予绒毛膜促性腺激素肌注治疗,比较两组患者的保胎成功率、症状缓解时间和治疗前后血清孕酮值的变化情况。结果:黄体酮组患者用药后的保胎成功率为93.55%高于绒毛膜促性腺激素组为70.97%(P<0.05)以及腹痛、腰酸缓解时间和止血时间分别为(3.32±1.02)d、(3.22±1.04)d和(3.91±1.01)d显著短于绒毛膜促性腺激素组为(8.26±2.51)d、(4.09±1.22)d和(6.69±2.71)d(P<0.05);黄体酮组患者治疗后测得血清孕酮值为(131.59±12.14)nmol/L,明显高于绒毛膜促性腺激素组为(102.61±9.22)nmol/L(P<0.05)。结论:黄体酮对早期先兆流产患者的症状缓解时间、血清孕酮值和保胎成功率均优于绒毛膜促性腺激素。
OBJECTIVE: To compare the duration of symptom relief and the success rate of miscarriage between progesterone and chorionic gonadotropin in patients with early threatened abortion. Methods: Sixty-two patients with early threatened abortion were selected from March 2010 to January 2012. They were randomly divided into progesterone group and chorionic gonadotropin group, with 31 cases in each group. Patients in progesterone group were given corpus luteum Ketone capsule oral treatment, chorionic gonadotropin group were given intramuscular injection of chorionic gonadotropin treatment, the success rate of miscarriage, symptom relief time and serum progesterone values before and after treatment were compared. Results: The progesterone success rate was 93.55% in progesterone group, 70.97% in chorionic gonadotropin group (P <0.05) and abdominal pain. The time for remission and stop bleeding time were (3.32 ± 1.02) days in progesterone group, (3.22 ± 1.04) d and (3.91 ± 1.01) d were significantly shorter than those in chorionic gonadotrophin group (8.26 ± 2.51 days, 4.09 ± 1.22 days and 6.69 ± 2.71 days, respectively; P < The serum progesterone level in the ketone group was (131.59 ± 12.14) nmol / L after treatment, which was significantly higher than that in the chorionic gonadotropin group (102.61 ± 9.22) nmol / L (P <0.05). CONCLUSION: Progesterone is superior to chorionic gonadotrophin in symptom relief, serum progesterone and miscarriage success rate in patients with early threatened abortion.