目前,肺癌是全世界发病率最高的恶性肿瘤,而侵袭与转移是恶性肿瘤最本质的生物学特征之一,约3/4的肺癌(lungcancer)患者在确诊时已发生远处转移[1]。近年来的研究表明,基质金属蛋白酶(m atrix m etalloprote inases,MMPs)及金属蛋白酶组织抑制剂(tissue in h ib itor of m etal At present, lung cancer is the highest incidence of malignant tumors in the world, and invasion and metastasis are one of the most essential biological features of malignant tumors. About three-fourths of lung cancer patients have been distantly metastasized at the time of diagnosis [1] . In recent years, studies have shown that matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (tissue in hibernation of m etal