【摘 要】
：
A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identific-ation of fourteen secondary metabolites(1-14)including eight sesquiterpenoids(1-8)and six polyphenols(9-14).Compounds 1-3 were sesquiterpe
【机 构】
：
State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 10010
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A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identific-ation of fourteen secondary metabolites(1-14)including eight sesquiterpenoids(1-8)and six polyphenols(9-14).Compounds 1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy,high resolution mass spectrometry(HRMS)and electronic circular dichroism(ECD)data.All the isolates were tested for their stimulation effects on glucose uptake in in-sulin-resistant HepG2 cells,and cellular antioxidant activity.Compounds 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus(SARS-CoV-2)activity.As a result,compounds 9-12 were found to increase the glucose up-take of insulin-resistant HepG2 cells by 18.1％,62.7％,33.7％and 21.4％at the dose of 50 μmol·L-1,respectively.Compounds 9-12 also showed good cellular antioxidant activities with CAA50 values of 12.23,23.1 1,5.31 and 16.04 μmol·L-1,respectively.Molecular docking between COVID-19 Mpro and compounds 9-12 indicated potential SARS-CoV-2 inhibitory activity of these four compounds.This work provides new insights for the potential role of the medicinal mushroom S.sanghuang as drugs and functional foods.
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