The flotation behavior of jamesonite was investigated with sodium diethyldithiocarbamate(DDTC) as a collector. The results show that jamesonite has good floatability from pH 2 to pH 13. The flotation of jamesonite is also dependent on the pulp potential. The potential-pH range for jamesonite flotation is established. The FTIR spectroscopy analysis shows that the major adsorption product of sodium diethyldithiocarbamate on jamesonite is lead diethyldithiocarbamate. The intensity of the FTIR signals of metal diethyldithiocarbamate adsorption on jamesonite and the flotation response of jamesonite are correlated with the pulp potential.