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取经病理证实的胃癌、结肠癌、胰腺癌组织共12例,正常胃,结肠粘膜4例,各取2g,制备可溶性抗原提取液,分别用ELISA方法检测MG5,MG9,MGd1MGel,MHb1相应抗原的含量,结果显示,MG单抗相应抗原在胃癌结肠癌组织中的分布均高于正常组织,但胰腺癌组织中则均为阴性。其中胃癌组织中的含量高于结肠癌组织,同一肿瘤组织中MG5,MG9,MGd1相应抗原的含量不同,但正常胃肠组织中也含有少量的MG单抗相应抗原,这一结果对探讨MG-Ags的表达机理及意义具有一定帮助。
Twenty-four cases of gastric cancer, colon cancer, and pancreatic cancer were confirmed pathologically, and 4 cases of normal stomach and colonic mucosa, 2 g each, to prepare a soluble antigen extract, and the corresponding antigen levels of MG5, MG9, MGd1MGel, and MHb1 were determined by ELISA. The results showed that the distribution of corresponding antigens of MG mAb in colon cancer tissues was higher than that in normal tissues, but negative in pancreatic cancer tissues. The content of gastric cancer tissue is higher than that of colon cancer tissue. The content of corresponding antigens of MG5, MG9, and MGd1 in the same tumor tissue is different, but normal gastrointestinal tissues also contain a small amount of corresponding antigen of MG monoclonal antibody. This result is to discuss MG- The expression mechanism and significance of Ags have some help.