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目的探讨足月新生儿血清促红细胞生成素(EPO)水平及其对临床疾病预测诊断价值。方法选择入院有窒息史或孕母有安胎史的新生儿40例,与足月健康儿15例,采用医学发光酶免疫分析法测定新生儿EPO水平。结果足月新生儿40例中足月小样儿EPO较正常对照组升高,差异有显著性(t=5.69P<0.01)。先天梅毒及先天愚型组EPO值较高(t=29.73P<0.01)。EPO升高者出生后逐步下降。窒息组、先天性心脏病(不含先天愚型)组、高胆红素组与正常对照组比较均无明显差异(t=0.199,0.024,0.347Pa>0.1)。结论新生儿EPO处于一个动态变化,出生后EPO升高能反映胎儿宫内慢性缺氧、宫内营养物质供应不足和宫内严重感染情况,出生后渐下降。出生后窒息或缺氧新生儿EPO测定并不能准确反映缺氧情况,可能受多因素影响。
Objective To investigate the serum level of erythropoietin (EPO) in full-term newborn and its value in predicting clinical disease. Methods Forty neonates with history of asphyxia or pregnancy history of fetus were enrolled in the study, and 15 healthy infants were enrolled in this study. The levels of EPO in neonates were determined by the method of chemiluminescence immunoassay. Results 40 cases of full-term neonates with full-term infant EPO increased compared with the normal control group, the difference was significant (t = 5.69P <0.01). Congenital syphilis and Down’s syndrome EPO value is higher (t = 29.73P <0.01). EPO rise gradually decreased after birth. Asphyxia group, congenital heart disease (without Down’s syndrome) group, no significant difference between high bilirubin group and normal control group (t = 0.199,0.024,0.347Pa> 0.1). Conclusion Neonatal EPO is in a dynamic state. After birth, the increase of EPO can reflect the chronic hypoxia in fetus, the supply of intrauterine nutrients and the intrauterine infection, and gradually decrease after birth. Asphyxia or hypoxia after birth, neonatal EPO determination does not accurately reflect the hypoxia, may be affected by many factors.