众所周知,二甲双胍是降糖药家族的元老之一,如果使用不当常常会出现常胃肠道反应,极少出现乳酸性酸中毒,鉴于此,指南建议禁用于肾功能不全的患者。英国前瞻性糖尿病研究(UKPDS)结果显示,与磺脲类药物或胰岛素相比,接受二甲双胍治疗的患者心肌梗死和死亡率显著下降。既往试验证实,二甲双胍可显著降低心血 As we all know, metformin is one of the veterans of the hypoglycemic drug family, if often used improper use will often gastrointestinal reactions, rare occurrence of lactic acidosis, in view of this, the guidelines suggest disabled patients with renal insufficiency. British Prospective Diabetes Study (UKPDS) results showed significant reductions in myocardial infarction and mortality in patients receiving metformin compared with sulfonylureas or insulin. Previous experiments confirmed that metformin can significantly reduce blood pressure