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目的探讨继发于原发性干燥综合征的低钾性周期性麻痹的临床特点、诊断及治疗方法。方法回顾分析2例以顽固性低钾性麻痹就诊于神经内科的患者。两名患者主要表现为发作性四肢无力,血钾水平低,经过常规补钾,血钾仍难以恢复正常。患者均发育欠佳,有口干超过3个月的症状,有眼部体征(Schirmer实验阳性),有涎腺受损证据(唾液流率阳性),自身抗体抗SSA(+),排除了其他潜在疾病后,诊断为原发性干燥综合征。诊断后给予激素治疗,同时口服枸橼酸合剂。结果患者血钾水平及肌力逐渐恢复正常,随访3个月及6个月,患者均能正常生活,未再发作四肢无力。结论对于顽固性低钾性周期性麻痹患者,需详细询问病史,特别留意是否合并肾小管酸中毒或全身其他系统病变的症状和体征,避免误诊和漏诊。
Objective To investigate the clinical characteristics, diagnosis and treatment of hypokalemic periodic paralysis secondary to primary Sjogren’s syndrome. Methods Retrospective analysis of 2 patients with intractable hypokalemic paralysis in neurology. Two patients mainly manifested as paroxysmal limb weakness, low blood potassium levels, after conventional potassium, potassium is still difficult to return to normal. Patients developed poorly with symptoms of dry mouth for more than 3 months, signs of ocular (Schirmer test positive), evidence of salivary gland damage (salivary flow positive), autoantibodies against SSA (+), exclusion of other After the underlying disease, the diagnosis of primary Sjogren’s syndrome. After the diagnosis of hormone therapy, while oral citrate mixture. Results The level of serum potassium and muscle strength gradually returned to normal. All patients were able to live normally for 3 months and 6 months after follow-up. Conclusions Patients with refractory hypokalemic periodic paralysis need to ask about their medical history in detail, paying particular attention to the symptoms and signs of renal tubular acidosis or systemic systemic diseases and avoiding misdiagnosis and missed diagnosis.