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目的 探讨Bcl 2蛋白与P 糖蛋白在胃癌发生、发展和耐药性产生中的作用以及二者间的相互关系。方法 应用免疫组化SP法检测胃癌组织中的Bcl 2蛋白与P 糖蛋白表达情况。结果 胃癌中Bcl 2蛋白阳性表达率为 37.5%,高分化腺癌和组织学Ⅰ级阳性表达率显著高于未分化癌和组织学Ⅲ级 (P <0 .0 5) ;P 糖蛋白阳性表达率为 30 .0 %,淋巴结转移和癌细胞浸润浆膜及浆膜外者表达率显著高于无淋巴结转移和浆膜内浸润者 (P <0 .0 5)。胃癌中Bcl 2蛋白与P 糖蛋白共同表达率为 2 1 .4%(P <0 .0 5)。结论 Bcl 2参与了胃癌的发生 ;P 糖蛋白阳性表达提示胃癌细胞对化疗药存在原发性耐药 ,同时与癌细胞浸润深度、淋巴结转移有关。胃癌中Bcl 2蛋白、P 糖蛋白的表达可能有一定的联系
Objective To investigate the roles of Bcl-2 and P-glycoprotein in the genesis, development and drug resistance of gastric carcinoma and their relationship. Methods Immunohistochemical SP method was used to detect the expression of Bcl 2 protein and P glycoprotein in gastric cancer tissues. Results The positive rate of Bcl-2 protein in gastric carcinoma was 37.5%. The positive rate of Bcl-2 protein expression in well-differentiated adenocarcinoma and histology was significantly higher than that in undifferentiated carcinoma and histological grade Ⅲ (P <0.05). The positive expression of P-glycoprotein The rate of lymph node metastasis and cancer cell infiltration was significantly higher than those without lymph node metastasis and serosal invasion (P <0.05). The rate of co-expression of Bcl-2 protein and P-glycoprotein in gastric cancer was 21.4% (P <0.05). Conclusions Bcl-2 is involved in the carcinogenesis of gastric cancer. The positive expression of P-glycoprotein suggests that gastric cancer cells have primary drug resistance to chemotherapeutic drugs, which is related to the depth of invasion and lymph node metastasis. Gastric cancer Bcl 2 protein, P glycoprotein expression may have some connection