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目的：探讨老年难治性高血压患者联合应用氨氯地平和氯沙坦钾氢氯噻嗪治疗的临床效果。方法：本院将2014年1月至2015年12月期间收治的64例老年难治性高血压患者，按照入院时间分为两组，分别为对照组和观察组，每组患者平均32例，给予对照组氨氯地平、美托洛尔、贝那普利联合治疗，观察组患者联合使用氨氯地平、美托洛尔、氯沙坦钾氢氯噻嗪治疗，对两组患者治疗效果进行评估。结果：在治疗效果方面，观察组患者总有效率高于对照组，具有可比性。两组患者治疗后血压与心率指标均得到改善，与治疗前比较，差异具备统计学意义；观察组患者治疗后收缩压、舒张压、心率等指标均要低于对照组，具有统计学意义。结论：针对老年难治性高血压患者，给予氨氯地平和氯沙坦钾氢氯噻嗪联合治疗，能够控制患者血压水平，改善心率，增强治疗效果，值得借鉴。“,”objective: to investigate the old patients with refractory hypertension combined use of ammonia chloride to peace temple potassium chloride sand hydrochlorothiazide clinical effect of treatment. Methods: in our hospital between January 2014 and December 2014 to admitted during the period of 64 cases of elderly patients with refractory hypertension, according to the admission time was divided into two groups, control group and observation group, respectively, an average of 32 patients with each group, control group amlodipine, metoprolol, bei that captopril combined treatment, observation group of patients with combined use of amlodipine and metoprolol, potassium chloride sand hydrochlorothiazide treatment, to evaluate therapeutic effect in both groups. Results: in terms of treatment, observation group total effective rate was higher than the control group, patients with comparable. Two groups of patients after treatment of blood pressure and heart rate are improved, compared with before treatment, difference have statistical signiifcance; Observation group after treatment in patients with systolic blood pressure, diastolic blood pressure, heart rate and other indicators are lower than the control group, with statistical signiifcance. Conclusion: in elderly patients with refractory hypertension, give peace ammonia chloride and potassium chloride sand jotham, hydrochlorothiazide combination therapy can control the patients blood pressure levels, improve the heart rate, enhance the treatment effect, is worth using for reference.