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报道我院外科从１９９２年１月至１９９５年１２月间对慢性乙肝伴肝胆结石病人行手术时，由于不能一次性取尽结石或解除狭窄，需行Ｔ管外引流胆汁者２９例的胆汁、外周血中的乙型肝炎表面抗原ＨＢｓＡｇ、ＨＢＶ－ＤＮＡ浓度进行了术时及术后的动态测定。结果：２９例在术中取胆汁和术后９０天胆汁中的ＨＢｓＡｇ浓度分别为１１８７．６５±３７０．９１μｇ／Ｌ、６２５．２１±２５３．７８μｇ／Ｌ，Ｐ＜０．１，但外引流胆汁９０天后有５例ＨＢｓＡｇ转阴；ＨＢＶ－ＤＮＡ在术时及术后９０天取Ｔ管胆汁测值分别为＋＋～＋，＋～０，且有３例转阴。随胆汁排放ＨＢＶ至体外，外周血ＨＢｓＡｇ、ＨＢＶ－ＤＮＡ浓度亦下降、术时外周血为２２４４．７３±５８７．２２μｇ／Ｌ，引流胆汁９０天后外周血ＨＢｓＡｇ为１２２５．４２±４４３．１７μｇ／Ｌ，Ｐ＜０．０５，ＨＢＶ－ＤＮＡ测值由术时＋＋～＋，引流胆汁９０天后外周血ＨＢＶ－ＤＮＡ测值为＋～０，不仅有降低趋势，且有３例转阴。
Report from our hospital from January 1992 to December 1995 for chronic hepatitis B patients with liver gallbladder surgery, because they can not be a one-time stone removal or stenosis, the need for T-tube drainage of bile in 29 cases of bile , HBsAg and HBV-DNA concentrations in peripheral blood were measured at the time of surgery and postoperatively. Results: The HBsAg concentrations of bile in 29 cases and 118 days after operation were 1187.65 ± 370.91μg / L and 625.21 ± 253.78μg / L respectively, P <0.1, but the external drainage Five cases of HBsAg were negative after 90 days of bile. The T-tube bile values of HBV-DNA were +++, +0, and 3 cases were negative at the time of operation and 90 days after operation. HBsAg and HBV-DNA in peripheral blood also decreased with the excretion of HBV in vitro. Peripheral blood was 2244.73 ± 587.22μg / L during surgery, and HBsAg in peripheral blood was 1225.42 ± 443.17μg / L after drainage for 90 days , P <0.05. The detection of HBV-DNA was +++ + during operation, and the value of HBV-DNA in peripheral blood was + 0 after 90 days of drainage, which not only decreased but also decreased in 3 cases.