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目的 总结鼻咽癌放疗后颌面部多原发癌的治疗经验。方法 回顾 11例鼻咽癌放疗术后口腔颌面部出现多原发癌患者的临床资料。结果 鼻咽癌放疗后口腔颌面部多原发癌患者因开口受限影响麻醉与手术视野 ,手术有一定难度 ;解剖层次不清 ,易损伤血管神经 ;局部组织再生能力低下影响伤口的愈合和皮瓣的生长 ;组织缺损大 ,需远处肌皮瓣转移修复 ;本组病例发生的多原发癌多数为高分化鳞癌 ,手术和再次放疗后 ,平均随访 5 .7年 ,死于指示肿瘤和第二肿瘤的死亡率为 45 .5 %。结论 鼻咽癌放疗后口腔颌面部多原发癌的治疗难度大 ,远期疗效不佳。
Objective To summarize the experience of multiple primary cancers in maxillofacial region after radiotherapy of nasopharyngeal carcinoma. Methods The clinical data of 11 patients with multiple primary cancers in oral and maxillofacial region after radiotherapy of nasopharyngeal carcinoma were retrospectively reviewed. Results Nasopharyngeal carcinoma patients with multiple primary cancers of oral and maxillofacial region had limited operation difficulty due to limited opening due to limited opening. The dissection level was unclear and the vascular nerves were easily damaged. The low local tissue regeneration affected the wound healing and Flap growth; tissue defects, the need for distant myocutaneous flap transfer repair; this group of cases of multiple primary cancers are highly differentiated squamous cell carcinoma, surgery and reradiation, the average follow-up 5.7 years, died in the instructions The mortality rate of tumors and second tumors was 45.5%. Conclusion The treatment of multiple primary cancers in oral and maxillofacial region after nasopharyngeal carcinoma is difficult to treat and long-term curative effect is poor.