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目的研究坎地沙坦联合贝那普利治疗原发性高血压的临床效果。方法 68例原发性高血压患者,随机分为B组与B+K组,每组34例。B组采用单纯贝那普利进行治疗,B+K组采用坎地沙坦联合贝那普利进行治疗。比较两组患者原发性高血压控制效果,治疗前后舒张压、收缩压水平的差异,及血脂、血糖不良影响情况。结果 B+K组治疗总有效率97.06%高于B组的73.53%,差异具有统计学意义(P<0.05)。治疗前两组舒张压、收缩压水平比较差异均无统计学意义(P>0.05);治疗后B+K组舒张压、收缩压水平优于B组,差异均具有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论坎地沙坦联合贝那普利治疗原发性高血压的临床效果确切,可有效改善患者血压水平,且对血脂、血糖无不良影响,值得推广应用。
Objective To study the clinical effect of candesartan and benazepril in the treatment of essential hypertension. Methods 68 patients with essential hypertension were randomly divided into group B and B + K group, 34 cases in each group. Group B was treated with benazepril alone and group B + K was treated with candesartan and benazepril. The control effects of essential hypertension in two groups were compared. The changes of diastolic blood pressure and systolic blood pressure before and after treatment were compared, and the adverse effects of blood lipids and blood glucose were compared. Results The total effective rate of B + K group was 97.06%, which was significantly higher than that of B group (73.53%, P <0.05). There was no significant difference in diastolic blood pressure and systolic blood pressure before treatment between the two groups (P> 0.05). After treatment, the diastolic blood pressure and systolic blood pressure were significantly higher in B + K group than in B group (P <0.05) ). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Candesartan combined with benazepril treatment of essential hypertension clinical effect is exact, can effectively improve the patient’s blood pressure level, and no adverse effects on blood lipids, blood glucose, it is worth promoting the application.