论文部分内容阅读
目的探讨肺癌患者肺部真菌发病的易感因素、常见真菌致病菌及药敏结果。方法回顾性分析73例肺癌患者肺部真菌感染的临床资料。结果肺癌肺部真菌感染主要以(白色念珠菌59%、热带念珠菌19%)为主,肺部真菌的药敏结果(5-氟胞嘧啶91%、氟康唑74%)氟康唑抗菌谱广、毒性低临床首选治疗药物,肺癌真菌感染患者易感因素(放化疗、长期应用广谱抗生素、应用糖皮质激素、应用免疫调节剂、呼吸道侵入性操作)与对照组相比(P<0.05)。结论老年肺癌真菌感染机会也明显增多,其中以白色念珠菌感染占首位,氟康唑是临床首选治疗药物,控制肺部真菌感染易感因素。
Objective To investigate the susceptibility factors of pulmonary fungal pathogenesis in patients with lung cancer, common fungal pathogens and susceptibility results. Methods The clinical data of lung fungal infection in 73 patients with lung cancer were retrospectively analyzed. Results Pulmonary fungal lung infections were mainly caused by Candida albicans (59% of Candida albicans and 19% of Candida tropicalis). The antibiotic susceptibility of pulmonary fungi (91% of 5-fluorocytosine and 74% of fluconazole) Compared with the control group (P <0.05), the broad-spectrum and low toxicity drugs were the first choice of therapies in patients with lung cancer fungal infection (radiotherapy and chemotherapy, long-term use of broad-spectrum antibiotics, glucocorticoid application of immunomodulators and invasiveness of respiratory tract) 0.05). Conclusions The chances of fungal infection in elderly patients with lung cancer are also obviously increased. Candida albicans infection accounts for the first place and fluconazole is the first choice for clinical treatment, which is a predisposing factor to control pulmonary fungal infection.