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2只beagle犬双侧下颌第3、4前磨牙和第1磨牙制备根分叉病变,分别植入胶原膜(空白对照组)、胶原膜-矿化诱导的BMSCs复合物(矿化诱导组)和胶原膜-非矿化诱导的BMSCs复合物(非矿化诱导组),术后12周组织学观察牙周组织再生情况。结果:新生牙槽骨面积和新生牙骨质长度的百分比,矿化诱导组(62.31±15.45和72.34±17.42)和非矿化诱导组(48.24±12.34和52.25±15.45)显著高于空白组(24.65±10.35和25.34±9.45)(P<0.05),但矿化诱导
The root bifurcation lesion was made in the two beagle dogs, the third and fourth premolar and the first molars in bilateral mandibular canines, respectively. Collagen membrane (blank control group), collagen membrane-mineralized BMSCs complex (mineralization induction group) And collagen membrane - non-mineralized induced BMSCs complex (non-mineralized induction group). The regeneration of periodontal tissues was observed histologically 12 weeks after operation. Results: The percentage of nasal alveolar bone area and newborn alveolar bone length were significantly higher in the mineralization induction group (62.31 ± 15.45 and 72.34 ± 17.42) and non-mineralization induction group (48.24 ± 12.34 and 52.25 ± 15.45) than in the blank group 24.65 ± 10.35 and 25.34 ± 9.45) (P <0.05), but mineralization was induced