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目的研究扶正护脑胶囊对脑出血大鼠心肌组织中TXB2和6-Keto-PGF1α含量的影响及其作用机制。方法60只动物随机分为假手术组、模型组、扶正护脑组和安宫牛黄组,分别于术后6、24、72h3个时相点取材,采用放免的方法检测心肌组织中TXB2和6-Keto-PGF1α的含量并观察其T/K比值的变化。结果模型组心肌TXB2含量显著增加,两个治疗组心肌TXB2含量均显著减少,术后6、24h安宫牛黄组降低TXB2的幅度大于扶正护脑组,术后72二者无显著性差异;模型组心肌6-Keto-PGF1α含量轻度增加,两个治疗组心肌6-Keto-PGF1α含量均有下降趋势,但无统计学意义;模型组心肌T/K比值显著增加,两个治疗组均显著降低,术后6、24h安宫牛黄组降低情况优于扶正护脑组,术后72h二者无显著差异。结论TXB2/6-Keto-PGF1α的比例失调是脑出血后心肌损伤的主要病理机制之一,扶正护脑胶囊能纠正T/K的失衡状态。
Objective To study the effect and mechanism of Fuzhenghounao Capsule on the contents of TXB2 and 6-Keto-PGF1α in myocardial tissue of rats with intracerebral hemorrhage. Methods Sixty animals were randomly divided into sham-operated group, model group, Fuzheng protecting brain group and Angong Niuhuang group. The rats were obtained at 3, 6, and 72 hours after operation. TXB2 and 6 in myocardial tissue were detected by radioimmunoassay. The content of -Keto-PGF1α was observed and its T/K ratio was observed. Results The myocardial TXB2 content in the model group increased significantly. The myocardial TXB2 content in the two treatment groups were significantly decreased. The TXB2 amplitude was lower in the Angong Niuhuang group than in the Fuzhenghong group at 6, 24 h after operation. There was no significant difference between the two groups. The content of 6-Keto-PGF1α in myocardium increased slightly in the myocardium. The contents of 6-Keto-PGF1α in myocardium decreased in both treatment groups, but there was no statistical significance. The T/K ratio in myocardium of the model group increased significantly, and both treatment groups were significantly increased. Decreased, after 6 and 24 hours, the reduction of the Angong Niuhuang group was better than that of the righting and protecting brain group, and there was no significant difference between the two groups after 72 hours. Conclusion The imbalance of TXB2/6-Keto-PGF1α is one of the main pathological mechanisms of myocardial injury after intracerebral hemorrhage. Fuzheng Huonao capsule can correct the imbalance of T/K.