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目的探讨纤维蛋白原(FBG)在砷中毒患者血浆检测中的临床意义。方法收集湖南省职业病防治院从2012年7月—2013年12月确诊为砷中毒的患者84例(砷中毒组)和健康检查正常者84例(对照组)抽取静脉血分别进行FBG、凝血酶原时间(PT)、白蛋白(ALB)等3项测定,并对所有结果进行统计分析。结果砷中毒组FBG、ALB检测结果均明显低于对照组,差异有统计学意义(P<0.01),PT检测结果差异并无统计学意义。且砷中毒治疗后FBG含量明显高于治疗前,差异有统计学意义(P<0.01)。结论 FBG检测对于砷中毒的诊疗具有较大价值,可以作为一种较为理想的辅助诊断砷中毒的指标。
Objective To investigate the clinical significance of detecting fibrinogen (FBG) in plasma of arsenic poisoning patients. Methods Eighty-four cases of arsenic poisoning (arsenic poisoning group) and 84 healthy controls (control group) were collected from Hunan Occupational Disease Prevention and Treatment Hospital from July 2012 to December 2013. Venous blood samples were collected for determination of FBG, thrombin The original time (PT), albumin (ALB) and other three measurements, and all the results for statistical analysis. Results The results of FBG and ALB in arsenism poisoning group were significantly lower than those in control group (P <0.01). There was no significant difference in the results of PT test. And the arsenic poisoning FBG content was significantly higher than before treatment, the difference was statistically significant (P <0.01). Conclusion The detection of FBG is of great value in the diagnosis and treatment of arsenicosis, which can be used as an ideal indicator to diagnose arsenicosis.