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Objective:To investigate the effects of static magnetic field(SMF) on the viability,adhesion molecule expression of human umbilical vessel endothelial cell.Methods:Magnetic flux intensity was 0.1 mT,1 mT,10 mT.Cell viability and proliferation were measured with 3H-TdR and MTT methods; and apoptosis of human umbilical vein endothelial cell (HUVEC) was studied by flow cytometry and transmission electric microscopy.ELISA was used to measure the expression of ICAM-1 and VCAM-1 on endothelium.Results:0.1 mT SMF had no effects on the growth of HUVEC,however,SMF of 1 mT,10 mT attenuated growth of HUVEC.10 mT static magnetic field could induce apoptosis and necrosis of HUVEC.10 mT SMF enhanced the expression of ICAM-1 and VCAM-1 on endothelium.Conclusion:The effect of SMF depends on the intensity of SMF.10 mT SMF has adverse effects on human umbilical vessel endothelial cell.