论文部分内容阅读
目的:研究并分析丙戊酸(VPA)联合拉莫三嗪(LTG)针对各型癫痫进行治疗过程中的临床疗效及其安全性。方法:选取我院自2010年1月～2011年1月所收治的癫痫病患者150例为研究对象,按照随机抽取方式将患者划分为治疗组与对照组,每组各计75例。治疗组患者给予丙戊酸(VPA)联合拉莫三嗪(LTG)治疗方案,对照组给予丙戊酸(VPA)治疗方案,随访9个月后两组患者各型癫痫的治疗疗效及安全性进行详细记录与分析。结果:治疗组患者随访9个月后各型癫痫的治疗疗效明显优于对照组患者,治疗组患者随访9个月内出现不良反应的发生率明显低于对照组患者,以上数据组间比较差异显著(p<0.05),差异有统计学意义。结论:丙戊酸(VPA)联合拉莫三嗪(LTG)在针对各型癫痫进行治疗的过程当中,疗效显著,远期疗效客观,不良反应少,安全性高在,值得临床应用与推广。
Objective: To study and analyze the clinical efficacy and safety of valproic acid (VPA) plus lamotrigine (LTG) in the treatment of various types of epilepsy. Methods: 150 cases of epilepsy patients admitted in our hospital from January 2010 to January 2011 were selected as the research object. Patients were divided into treatment group and control group according to random sampling method, with 75 cases in each group. Patients in the treatment group were treated with valproic acid (VPA) combined with lamotrigine (LTG) and control group with valproic acid (VPA). The therapeutic efficacy and safety of each type of epilepsy in both groups were followed up for 9 months Detailed record and analysis. Results: The therapeutic effect of various types of epilepsy was significantly better in the treatment group than in the control group at 9 months of follow-up. The incidence of adverse reactions in the treatment group within 9 months of follow-up was significantly lower than that in the control group. Significant (p <0.05), the difference was statistically significant. Conclusions: Valproic acid (VPA) combined with lamotrigine (LTG) has significant curative effect in the treatment of various types of epilepsy. Its long-term curative effect is objective, with few adverse reactions and high safety. It is worthy of clinical application and promotion.