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目的:了解前循环急性多发脑梗死(AMBI)发病危险因素及病因分析。方法:连续收入73例前循环AMBI患者为试验组,随机收集73例同期入院的前循环急性单发脑梗死(ASBI)患者为对照组。对可能影响AMBI发病的14个危险因素分别进行单因素分析及多元Logistic逐步回归分析。病因分型采用改良TOAST分型方法。结果:AMBI组与ASBI组相比,高血压病、糖尿病、心房颤动、吸烟、年龄及入院时收缩压等危险因素两组间差异有统计学意义。Logistic回归分析显示,年龄(OR=1.03,95%CI:1.01~1.13)、高血压(OR=2.78,95%CI:1.06~7.58)、心房颤动(OR=3.19,95%CI:1.13~9.07)为AMBI发病独立危险因素。与ASBI患者相比,48例一侧半球AMBI患者,动脉粥样硬化血栓形成是其主要病因(P=0.03);25例双侧半球AMBI患者,心源性栓塞是其主要病因(P=0.01)。结论:年龄、高血压病、心房颤动为AMBI发病独立危险因素。动脉粥样硬化血栓形成是一侧半球AMBI患者主要病因;心源性栓塞是双侧半球AMBI患者主要病因。
Objective: To understand the risk factors and causes of acute anterior circulation multiple brain infarction (AMBI). Methods: A total of 73 patients with AMBI in the anterior circulation were enrolled as the experimental group, and 73 patients with ASBI admitted in the same period were randomly selected as the control group. Univariate analysis and multivariate logistic regression analysis of 14 risk factors that may affect the incidence of AMBI. Etiological classification using improved TOAST classification method. Results: Compared with ASBI group, the risk factors of hypertension, diabetes mellitus, atrial fibrillation, smoking, age and admission systolic pressure in AMBI group were statistically different. Logistic regression analysis showed that age (OR = 1.03, 95% CI: 1.01-1.13), hypertension (OR = 2.78, 95% CI 1.06-7.58), atrial fibrillation (OR = 3.19, 95% CI 1.13-9.07 ) Is an independent risk factor for the onset of AMBI. Compared with patients with ASBI, atherosclerosis thrombosis was the major cause in 48 patients with hemispheric AMBI (P = 0.03). Cardiac embolism was the main cause in 25 patients with bilateral hemispheric AMBI (P = 0.01 ). Conclusion: Age, hypertension and atrial fibrillation are independent risk factors of AMBI. Atherosclerosis thrombosis is the main cause of hemisphere AMBI; cardioembolism is the major cause of bilateral hemispheric AMBI.