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目的调查和分析临床分离的耐甲氧西林金黄色葡萄球菌(MRSA)菌株耐药情况和对3种消毒剂的抗性情况。方法收集临床分离MRSA菌株16株进行药敏试验,测定其对乙醇、苯扎溴铵、戊二醛的MICs和MBCs,与金黄色葡萄球菌标准菌株(ATCC 6538)相比较,判断对消毒剂的抗性水平。结果 16株试验菌对18种抗菌药物产生耐药现象,呈现出13种耐药谱。分别有25%、31%和6%的MRSA菌株对乙醇、苯扎溴铵、戊二醛的MICs和MBCs高于标准株。结论临床分离的MRSA菌株对多种抗菌药物有较高耐药性,同时对苯扎溴铵和乙醇呈现抗性趋势;各种来源菌株的耐药性与消毒剂抗力大小无明显相关性。
Objective To investigate and analyze the clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains and resistance to three kinds of disinfectants. Methods 16 strains of clinical isolates of MRSA were collected for susceptibility testing. MICs and MBCs of ethanol, benzalkonium bromide and glutaraldehyde were determined. Compared with the standard strain of Staphylococcus aureus (ATCC 6538) Resistance level. Results 16 strains of test strains were resistant to 18 kinds of antibacterials, showing 13 kinds of drug resistance spectrum. The MICs and MBCs of 25%, 31% and 6% of MRSA isolates against ethanol, benzalkonium bromide and glutaraldehyde were higher than the standard strains respectively. Conclusion The clinical isolates of MRSA showed high resistance to various antimicrobial agents, and tended to be resistant to benzalkonium bromide and ethanol. There was no significant correlation between drug resistance and disinfectant resistance of various strains.