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目的:探讨6p21.1 rs2494938和7p15.3 rs2285947基因多态性与宫颈癌发生风险的关联性。方法:以571例宫颈癌患者和657例非宫颈癌患者(对照组)为研究对象,用Taq Man MGB(minor grove binder)探针对6p21.1 rs2494938多态位点和7p15.3 rs2285947多态位点进行基因分型,分析不同基因型与宫颈癌发生风险的关联性。采用非条件Logistic回归分析统计该多态位点与宫颈癌遗传易感的关联性,计算相对危险度的比值比(OR)及95%置信区间(CI)。结果:rs2494938多态位点突变型GA和AA基因型频率在病例组和对照组的分布无显著差异(P=0.848)。rs2285947多态位点突变型GA和AA基因型频率在病例组和对照组的分布有显著差异(P=0.028);合并突变基因型(GA+AA)与野生型GG相比宫颈癌发生风险显著下降(OR=0.77,95%CI:0.62~0.97,P=0.025)。结论:rs2494938多态性与宫颈癌发生风险无显著关联,rs2285947多态性与宫颈癌发生风险有显著关联。
Objective: To investigate the association between the polymorphisms of 6p21.1 rs2494938 and 7p15.3 rs2285947 and the risk of cervical cancer. Methods: A total of 571 cases of cervical cancer and 657 cases of non-cervical cancer (control group) were selected as research objects. The alleles of 6p21.1 rs2494938 polymorphism and 7p15.3 rs2285947 polymorphism were detected by Taq Man MGB (minor grove binder) Site genotyping, analysis of different genotypes and cervical cancer risk associated. Non-conditional logistic regression analysis was used to analyze the association of the polymorphic loci with genetic susceptibility to cervical cancer. The odds ratio (OR) and 95% confidence interval (CI) of relative risk were calculated. Results: There was no significant difference in the frequency of GA and AA genotypes between rs2494938 polymorphism loci and controls (P = 0.848). There was a significant difference in the distribution of GA and AA genotypes between rs2285947 polymorphism loci and control group (P = 0.028). The risk of cervical cancer was higher in combined genotype (GA + AA) than that in wild type GG Decreased (OR = 0.77, 95% CI: 0.62-0.97, P = 0.025). Conclusion: There is no significant correlation between rs2494938 polymorphism and the risk of cervical cancer. The rs2285947 polymorphism is significantly associated with the risk of cervical cancer.