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目的探讨CD1α、CD83阳性树突状细胞在肺癌组织中的浸润情况及其临床意义。方法采用流式细胞术检测49例非小细胞肺癌组织,对应的49例癌旁组织,10例炎性假瘤中树突状细胞表面分子CD1α和CD83的表达,分析CD1α和CD83表达水平与肺癌临床分期、病理类型、组织学分级和淋巴结转移的相关性。结果(1)树突状细胞CD1α的表达率在肺癌组织、癌旁组织及炎性假瘤中无显著性差异(P>0.05);(2)肺癌组织中CD83阳性树突状细胞的比例明显低于癌旁组织及炎性假瘤(P<0.05);(3)肺癌组织中树突状细胞CD83的表达率在不同临床分期、病理类型和组织学分级中无显著性差异(P>0.05),但与肺癌的局部淋巴结转移有关(P<0.05)。结论(1)肺癌组织中CD83阳性树突状细胞较癌旁组织及炎性组织中减少;(2)肺癌组织中CD83阳性树突状细胞减少与肿瘤淋巴转移密切相关。
Objective To investigate the infiltration of CD1α and CD83 positive dendritic cells in lung cancer and its clinical significance. Methods Flow Cytometry was used to detect the expression of CD1α and CD83 on dendritic cells in 49 cases of non-small cell lung cancer tissues, corresponding to 49 cases of paracancerous tissues and 10 cases of inflammatory pseudotumor. The expressions of CD1α and CD83 in lung cancer Clinical stage, pathological type, histological grade and lymph node metastasis. Results (1) The expression rate of CD1α in dendritic cells was not significantly different between lung cancer tissue, paracancer tissue and inflammatory pseudotumor (P> 0.05). (2) The proportion of CD83 positive dendritic cells in lung cancer was significantly (P <0.05). (3) The expression rate of CD83 in dendritic cells in lung cancer tissues had no significant difference in different clinical stage, pathological type and histological grade (P> 0.05) ), But with local lymph node metastasis (P <0.05). Conclusions (1) CD83 positive dendritic cells in lung cancer tissues are lower than those in paracancerous tissues and inflammatory tissues. (2) The decrease of CD83 positive dendritic cells in lung cancer tissues is closely related to tumor lymphatic metastasis.