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利拉鲁肽是一种人胰高血糖素样肽1类似物,有独特的作用机制,具有改善胰岛β细胞功能,促进胰岛β细胞分泌、减轻体质量等作用,不良反应少,是一种新型的降糖药,具有广阔的应用前景。脂联素是一种在脂肪细胞高度特异性表达、对人体有保护作用的脂肪因子,具有改善胰岛素抵抗、抗动脉粥样硬化、抑制炎症等作用,检测血清中脂联素的水平有重要意义。国内外在对小鼠的研究中发现,利拉鲁肽可能通过上调脂联素水平而改善胰岛素的敏感性。
Liraglutide is a human glucagon-like peptide analogue with a unique mechanism of action. It has the effect of improving pancreatic β-cell function, promoting the secretion of pancreatic β-cells, reducing body weight, New hypoglycemic agents, has broad application prospects. Adiponectin is a kind of adipokines that are highly expressed in adipocytes and have a protective effect on human body. It has the effects of improving insulin resistance, anti-atherosclerosis, inhibiting inflammation and detecting the level of adiponectin in serum . At home and abroad in the study of mice found that liraglutide may improve insulin sensitivity by upregulation of adiponectin.