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目的研究益肾温经汤对肾阳虚型排卵障碍大鼠的促排卵机理。方法将50只大鼠随机分为空白组,模型组,益肾温经汤高、低剂量组及中药对照组,以氢化可的松注射液肌肉注射建立肾阳虚型排卵障碍大鼠模型。灌胃治疗后,观察各组大鼠阴道脱落细胞涂片,子宫、卵巢、肾上腺指数及血清雌二醇(E2)、孕酮(P)的变化。结果益肾温经汤高剂量能够显著升高肾阳虚型排卵障碍大鼠的子宫、卵巢、肾上腺指数及血清E2、P水平(P<0.05),而益肾温经汤低剂量则作用不明显。结论益肾温经汤的促排卵作用可能与其升高雌、孕激素水平,增强卵巢功能,改善肾阳虚症状有关。
Objective To study the mechanism of promoting ovulation of Yishen Wenjing Decoction on ovulatory dysfunction rats with kidney yang deficiency. Methods 50 rats were randomly divided into blank group, model group, Yijing Wenjing Tanggao and low dose group and traditional Chinese medicine control group. The rat model of kidney yang deficiency ovulation disorder was established by intramuscular injection of hydrocortisone injection. After intragastric administration, the smears of vaginal exfoliated cells, uterus, ovary, adrenal gland index, serum estradiol (E2) and progesterone (P) were observed in all groups. RESULTS: High dose of Yishen Wenjing Decoction can significantly increase the uterus, ovary, adrenal index and serum E2 and P levels in rats with ovulatory deficiency of kidney-yang deficiency type (P<0.05). However, low dose of Yishen Wenjing Decoction is not effective. obvious. Conclusion The ovulation-promoting effect of Yishen Wenjing Decoction may be related to increasing estrogen and progesterone levels, enhancing ovarian function, and improving symptoms of kidney-yang deficiency.