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目的:探讨乳腺嗜酸细胞癌(OC)的临床病理特点及其鉴别诊断。方法:观察和分析1例乳腺嗜酸细胞癌的临床病理特点、免疫组化染色表达并复习文献。结果:癌细胞胞浆丰富,胞浆内见弥漫均匀分布的强嗜酸性颗粒,癌细胞呈腺性排列,呈圆形、多边形,边界清晰,细胞核异型性较小,核仁明显。免疫组化染色SMA、S100蛋白及CgA呈阴性表达,PAS染色阴性。结论:OC是一种少见的特殊类型浸润性乳腺癌,需与大汗腺癌、神经内分泌癌及颗粒细胞瘤等鉴别。
Objective: To investigate the clinicopathological features and differential diagnosis of breast eosinophilic carcinoma (OC). Methods: The clinicopathological features of one case of breast eosinophilic carcinoma were observed and analyzed. The expression of immunohistochemical staining and review of the literature were reviewed. Results: The cytoplasm of cancer cells was abundant. The eosinophilic granules diffusely distributed in the cytoplasm. The cancer cells were arranged in a glandular arrangement with a round and polygonal shape. The border was clear, the nucleus atypia was small, and the nucleoli were obvious. Immunohistochemical staining of SMA, S100 protein and CgA negative expression, PAS staining negative. Conclusion: OC is a rare and special type of invasive breast cancer and needs identification with apocrine, neuroendocrine and granulosa cell tumors.