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目的:探讨丝裂霉素C在泪道探通联合置管术治疗单纯性鼻泪管堵塞的临床效果。方法将180例单纯性鼻泪管堵塞患者随机分为丝裂霉素+泪道探通组(A组)、泪道探通组(B组)和泪道激光成形组(C组)。其中A组行泪道探通后,局部使用丝裂霉素C后再置管;B组行泪道探通后直接置管;C组行泪道激光成形后直接置管。治疗后随访1年,观察手术成功率。结果丝裂霉素+泪道探通组与单纯泪道探通组的疗效差异有统计学意义(P0.05)。结论在泪道探通联合置管术中使用MM-C能提高手术成功率;而在单纯性鼻泪管手术治疗中,是否使用激光,对手术成功率并无实质影响。“,”Objective To explore the clinical effects of Mitomycin-C in Lacrimal Probing Combine With Lacrimal Duct Surgery Planting in Treatment of Simple Lacrimal Duct Obstruction. Methods 180 patients with simple lacrimal duct obstruction were randomly divided into group A、group B and group C. Group A: after lacrimal probing, use Mitomycin-c before lacrimal duct surgery planting; Group B:Lacrimal probing combine with lacrimal duct surgery planting ; Group C:Lacrimal duct laser combine with lacrimal duct surgery planting.Observe the success rate of operation after following up one year. Results The success rate of group A was73.3%,higher than group B (51.67%),had difference statisticant significance (P0.05) between group B (51.67%) and group C(48.33%).Conclusion Mitomycin-c can improve the success rate in Lacrimal probing combine with lacrimal duct surgery planting in treatment of simple lacrimal duct obstruction.