目的　观察洛度沙胺滴眼液联合丝裂霉素C预防胬肉复发的作用。方法　对 6 5例 (71眼 )原发性和复发性翼状胬肉随机分为两组 ,治疗组 34例 (38眼 ) ,对照组 31例 (33眼 )。两组均施行胬肉切除加带蒂结膜瓣移位术 ,治疗组术后滴用 0 1%洛度沙胺滴眼液 ,每天 4次 ,共 3个月 ,同时滴用 0 1g/L丝裂霉素C ,每天 2次 ,共 6d ,随访 11～ 2 0个月 ,平均 13个月。结果　 2例 (2眼 )失访。治疗组翼状胬肉复发率2 70 % ,对照组复发率 31 2 5 % ,P <0 0 1,治疗组角膜创面愈合延迟。 4例结膜切口裂开 ,9例有浅层点状角膜炎。结论　翼状胬肉切除加带蒂结膜瓣移位术后滴用 0 1%洛度沙胺滴眼液联合 0 1g/L丝裂霉素C能有效地预防翼状胬肉复发 ,但出现部分并发症。 Objective To observe the effect of loraldamide eye drops combined with mitomycin C in preventing recurrence of pterygium. Methods Sixty-five cases (71 eyes) of primary and recurrent pterygium were randomly divided into two groups: 34 cases (38 eyes) in the treatment group and 31 eyes (31 eyes) in the control group. Two groups were performed pterygium resection plus pedicle conjunctival flap shift, the treatment group after drip with 0 1% lodamine sand eye drops 4 times a day for 3 months, while dripping with 0 1g / L silk Ciclomycin C, 2 times a day, a total of 6d, followed up 11 ~ 20 months, an average of 13 months. Results 2 cases (2 eyes) were lost. In the treatment group, the recurrence rate of pterygium was 70 70% in the control group and 31 25% in the control group, P <0.01. The corneal wound healing in the treatment group was delayed. 4 cases of conjunctival incision rupture, 9 cases of shallow punctate keratitis. Conclusion Pterygium excision and pedicle conjunctival flap displacement after the drop with 0 1% lodamine sand eye drops combined with 0 1g / L mitomycin C can effectively prevent the recurrence of pterygium, but some complications .