目的 :探讨生活事件与食管癌发生的关系。方法 :采用 1∶2配对病例对照研究。病例组为 1997年 12月安阳县某 3个乡食管癌普查中发现的全部现症食管癌患者。全部病例经细胞学和病理学确诊 ,且全部为鳞癌。对照组从普查中的非食管癌患者中选取。配比条件 :①与病例同性别。②年龄相近 ,与病例年龄相差小于 5岁。③居住地相同 ,与病例同村。结果 :病例组负性事件发生率 (33.9% )显著高于对照组 (14.3% ) ;经单因素和Logistic回归分析发现邻里和睦 (OR =0 15 )、丧偶 (OR =19)、家属重病或亡故 (OR =5 6 3)、经济状况恶化 (OR =4 46 )与食管癌发生有显著联系。结论 :邻里和睦为食管癌保护因素 ,丧偶、家属重病或亡故、经济状况恶化为食管癌危险因素。负性事件为食管癌的危险因素。 Objective: To explore the relationship between life events and the occurrence of esophageal cancer. Methods: A 1:2 matched case-control study was used. The case group was all esophageal cancer patients found in a survey of esophageal cancer in 3 townships in Anyang County in December 1997. All cases were confirmed by cytology and pathology, and all were squamous cell carcinoma. The control group was selected from non- esophageal cancer patients in the census. Matching conditions: 1 case and the same sex. 2 are similar in age, and the age difference is less than 5 years old. 3 Same place of residence, the same village as the case. Results: The incidence of negative events in the case group (33.9%) was significantly higher than that in the control group (14.3%); univariate and Logistic regression analysis revealed that the neighborhood and deafness (OR=015), widowed (OR=19), family members were seriously ill or Death (OR = 563) and deteriorated economic status (OR = 4 46) were significantly associated with esophageal cancer. Conclusion: Neighbourhood and deafness are protective factors for esophageal cancer. Widowed, family members are seriously ill or dead, and economic conditions worsen are risk factors for esophageal cancer. Negative events are risk factors for esophageal cancer.