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目的:评价南京地区医院大环内酯类抗菌药物的利用情况。方法:采用回顾性方法,对南京地区33家医院2009-2011年大环内酯类抗菌药物的销售金额、用药频度(DDDs)等进行统计、分析。结果:该地区医院大环内酯类抗菌药物的销售金额及总DDDs各年度均有所降低,年均降幅分别为9.77%和8.23%。品种方面,2010-2011年较2009年增加了2种,即螺旋霉素和地红霉素。第2代大环内酯类的用量远大于第1代,占整个大环内酯类的94.97%。各年度销售金额及DDDs排序列前3位的药物为阿奇霉素、克拉霉素、罗红霉素;销售金额排序列前3位的生产厂家为江苏扬子江药业、江苏恒瑞医药集团、辽宁沈阳第一制药厂;销售金额排序列前5位的产品为罗红霉素细粒剂(仁苏)、克拉霉素缓释片(诺邦)、克拉霉素分散片(锋锐)、阿奇霉素胶囊(希舒美)、注射用乳糖酸阿奇霉素(其仙)。结论:该地区医院大环内酯类抗菌药物的应用呈下降趋势,应用排序列前3位的是阿奇霉素、克拉霉素、罗红霉素,均为第2代大环内酯类。
Objective: To evaluate the utilization of macrolide antibiotics in hospitals in Nanjing. Methods: A retrospective analysis was conducted on the sales amount, frequency of DDDs, etc. of macrolide antibiotics in 33 hospitals in Nanjing in 2009-2011. Results: The sales volume of macrolide antibiotics in hospitals in the area and total DDDs decreased in each year, with an average annual decline of 9.77% and 8.23% respectively. Varieties, 2010-2011 increased by two kinds compared with 2009, that is, spiramycin and erythromycin. The second generation macrolides dosage is much larger than the first generation, accounting for 94.97% of the total macrolides. The sales amount and DDDs in each year ranked the top 3 drugs for azithromycin, clarithromycin and roxithromycin; the top 3 manufacturers in terms of sales amount were Jiangsu Yangtze River Pharmaceutical, Jiangsu Hengrui Pharmaceutical Group, Liaoning Shenyang A pharmaceutical factory; sales amount of the top 5 products ranked roxithromycin granules (Ren Su), clarithromycin sustained release tablets (Norbon), clarithromycin dispersion tablets (Feng Rui), azithromycin capsules ( Shishimei), injection of azithromycin lactobionate (its fairy). CONCLUSION: The application of macrolide antibiotics in hospitals in this area is on the decline. Azithromycin, clarithromycin and roxithromycin are the top three most commonly used macrolides in the area, all of which are the second generation macrolides.