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目的寻找一种更为安全有效的异位妊娠药物治疗方法。方法将58例异位妊娠患者随机分为氨甲喋呤(MTX)联合米非司酮(Ru 486)组(实验组)和氨甲喋呤组(对照组),分别观察两组第1疗程、第2疗程治愈率及总治愈率,血β-HCG 降至正常时间和药物副反应发生率。结果两组总治愈率及各疗程治愈率无显著性差异(P>0.05),但实验组血β-HCG 降至正常时间短于对照组,经比较差异有显著性(P<0.05);且实验组 MTX 用量小、疗程短,用药后副反应发生率明显低于对照组。结论 MTX 联合 Ru486治疗异位妊娠具有疗效高、疗程短、副反应少的优点,值得临床推广。
Objective To find a safer and more effective ectopic pregnancy drug treatment. Methods 58 cases of ectopic pregnancy were randomly divided into methotrexate (MTX) combined with mifepristone (Ru 486) group (experimental group) and methotrexate group (control group), the first two courses were observed, the second course of cure rate And the total cure rate, blood β-HCG decreased to normal time and drug side effects. Results There was no significant difference between the two groups (P> 0.05), but the difference between the two groups was statistically significant (P <0.05). The experimental group MTX dosage is small, short course of treatment, the incidence of side effects after treatment was significantly lower than the control group. Conclusion MTX combined Ru486 treatment of ectopic pregnancy has the advantages of high efficacy, short course of treatment, fewer side effects, worthy of clinical promotion.