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目的:探讨前列腺基底细胞癌(basal cell carcinoma of prostate)的发生、临床病理特点、病理诊断、鉴别诊断以及治疗和预后。方法:运用HE染色及免疫组化染色对5例前列腺基底细胞癌进行临床病理学分析,并结合相关文献进行分析。结果:前列腺基底细胞癌癌细胞排列成筛孔状或实性巢状,细胞体积较小,细胞核大并呈卵圆形,大小一致,胞质少,可见核分裂像。肿瘤呈浸润性生长,肿瘤组织中34βE12、P63、CK14呈阳性表达,PSA、P504S蛋白常呈阴性表达。术后随访至少12个月以上,均未见肿瘤复发及转移。结论:前列腺基底细胞癌为一种不同于前列腺腺癌的罕见肿瘤,免疫组化对于鉴别前列腺基底细胞癌和其他肿瘤有重要的作用,其生物学行为尚有争议,目前多数学者主张通过完整切除并联合放化疗的方式来治疗。
Objective: To investigate the occurrence, clinicopathological features, pathological diagnosis, differential diagnosis, treatment and prognosis of basal cell carcinoma of prostate. Methods: The clinical and pathological features of 5 cases of prostatic basal cell carcinoma were analyzed by HE staining and immunohistochemical staining, and the related literatures were analyzed. Results: The basal cell carcinoma of prostate cancer cells arranged in a mesh or solid nests, smaller cells, large and oval nucleus, the same size, less cytoplasm, mitotic image. The tumors showed invasive growth. The expression of 34βE12, P63 and CK14 in the tumor tissues was positive, while the expression of PSA and P504S in the tumors was negative. All patients were followed up for at least 12 months, no tumor recurrence and metastasis were found. Conclusions: Prostatic basal cell carcinoma is a rare tumor different from prostatic adenocarcinoma. Immunohistochemistry plays an important role in the differential diagnosis of prostatic basal cell carcinoma and other tumors. Its biological behavior is still controversial. At present, most scholars advocate complete pruning And combined radiotherapy and chemotherapy approach to treatment.