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本文对幽门螺杆菌(HP)与慢性胃炎的关系,HP的生物学特性、诊断方法、治疗学等方面进行了系列研究。在100例消化不良患者中HP的阳性率在慢性浅表性胃炎为80.8％(51/63),慢性萎缩性胃炎为75％(15/20),而正常胃粘膜中为11.7％(2/17)。电镜下,HP寄居处胃粘膜微绒毛变稀疏或消失,上皮细胞粘液颗粒减少,而当HP清除后胃粘膜超微结构恢复正常,这些均提示HP的致病性。HP对酸是敏感的,其产生的尿素酶分解胃液中的尿素产氨起到了自身抗酸保护作用,此举有助于HP在胃中高酸环境中生存,并由此可以通过测定胃液尿素氮(GUN)含量来诊断HP感染。对多种诊断HP的方法进行了对比分析,认为改良Giemsa染色法和快速尿素酶试验可满足临床应用。用庆大霉素、铋剂治疗HP阳性的慢性胃炎、消化性溃疡患者取得了肯定的疗效。
In this paper, Helicobacter pylori (HP) and chronic gastritis, the biological characteristics of HP, diagnosis, treatment and other aspects of a series of studies. In 100 patients with dyspepsia, the positive rate of HP was 80.8% (51/63) in chronic superficial gastritis, 75% (15/20) in chronic atrophic gastritis, and 11.7% (2 / 17). Under electron microscopy, micro-villi in gastric mucosa of HP colonies became sparse or disappear, and mucus granules in epithelial cells decreased. When the ultrastructure of gastric mucosa returned to normal after HP was removed, all these suggested the pathogenicity of HP. HP is sensitive to acid, and the urease produced by it decomposes urea in the gastric juice to produce ammonia, which has its own antacid protection effect. This action helps HP to survive in the high acid environment in the stomach, and thus can measure the gastric fluid urea nitrogen (GUN) content to diagnose HP infection. A variety of methods to diagnose HP were compared and analyzed, that the modified Giemsa staining and rapid urease test to meet the clinical application. With gentamicin, bismuth treatment of HP-positive chronic gastritis, peptic ulcer patients have achieved a positive effect.