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目的:观察术后高压氧加放疗治疗脑瘤的临床疗效。方法:选择脑瘤术后60例,随机分为单纯放疗组(对照组)及高压氧加放疗组(观察组)各30例。比较两组局控率、中位肿瘤进展时间(TTP)、年生存率和不良反应发生情况。结果:观察组局控率、中位TTP显著或非常显著高于对照组(P<0.05或P<0.01)。观察组2、3年生存率与对照组比较,差异显著(P<0.05)。观察组发生放射性脑病5例,占16.7%;对照组9例,占30.0%,两组比较,差异显著(P<0.05)。结论:高压氧加放疗可提高脑瘤术后的局控率、改善中位TTP和减轻不良反应。
Objective: To observe the clinical effect of postoperative hyperbaric oxygen plus radiation therapy on brain tumor. Methods: Sixty patients with brain tumor were randomly divided into radiotherapy group (control group) and hyperbaric oxygen plus radiotherapy group (30 cases). The two groups of control rate, median tumor progression time (TTP), annual survival rate and adverse reactions were compared. Results: The local control rate and the median TTP in the observation group were significantly or very significantly higher than those in the control group (P <0.05 or P <0.01). The 2-year and 3-year survival rates in the observation group were significantly different from those in the control group (P <0.05). Radiation encephalopathy occurred in observation group in 5 cases, accounting for 16.7%; control group, 9 cases, accounting for 30.0%. There was significant difference between the two groups (P <0.05). Conclusion: Hyperbaric oxygen plus radiotherapy can increase the rate of postoperative brain tumor control, improve the median TTP and reduce adverse reactions.