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灼口综合征(Burning mouth syndrome,BMS)是一种以口腔黏膜烧灼样疼痛为特征的慢性疼痛,常不伴有器质性损害。BMS的病因和发病机制不明确,亦缺乏公认的诊断标准,因此对BMS的治疗仍是一个难题。神经病理性疼痛(Neuropathic pain,NP)被认为是疾病影响外周或中枢神经系统的躯体感觉传导途径的结果,发生在各种神经源性疾病当中,人群发病率达到6%~8%,对人的生活、情绪和睡眠质量有很大影响。目前一些研究认为BMS是一种NP,应用NP的诊断标准和治疗方法将可能成为解决BMS治疗难题的突破点之一。本文将从BMS是NP的证据、应用NP的诊断标准诊断BMS、应用NP的治疗方法治疗BMS三个方面进行综述。
Burning mouth syndrome (BMS) is a chronic pain characterized by burning-like pain in the oral mucosa, often without organic damage. BMS etiology and pathogenesis is not clear, but also the lack of recognized diagnostic criteria, so the treatment of BMS is still a problem. Neuropathic pain (NP) is thought to be the result of a somatosensory pathway that affects the peripheral or central nervous system. It occurs in various neurogenic diseases with a prevalence of 6% to 8% in humans, Life, mood and quality of sleep have a huge impact. At present, some studies think that BMS is an NP, and the application of NP diagnostic criteria and treatment methods will be one of the breakthrough points to solve the BMS treatment problems. This article will review the evidence that BMS is NP, the diagnosis of BMS using the diagnostic criteria of NP, and the treatment of BMS with NP.