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本文完成了一种具有潜在转移活性的层粘连蛋白核心三糖β-D-Gal-(1→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-OMe的合成。以2-碘代叠氮乳糖为供体采用“叠氮碘糖基化”反应一步完成了2-脱氧-2-氨基乳糖结构及1,2-反式-氨基乳糖糖苷键的立体选择性构建。这种方法能简易、高效地合成含氨基乳糖的寡糖,较好地避免了直接使用活性较差的2-氨基糖衍生物构建氨基乳糖模块。
In this paper, we have completed the synthesis of a laminin core trisaccharide β-D-Gal- (1 → 4) -β-D-GlcpNAc- (1 → 6) -α-D-Manp-OMe with potential metastatic activity. The 2-deoxy-2-amino lactose structure and the stereoselectivity of 1,2-trans-aminogalactoside bond were completed in one step using 2-iodo-azidated lactose as donor. Sex building. This method can easily and efficiently synthesize lactose-containing oligosaccharides and avoid the direct use of the less active 2-aminosugar derivatives for constructing the lactam lactam moiety.